

Metabolomics core facility
Metabolomics, or metabonomics, refers to the measurement of metabolites (compounds with a molecular mass < 1000 daltons) in biological materials such as blood, urine, cells.
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In the Faculty we are able to perform both untargeted and targeted metabolomics. Untargeted metabolomics, also referred to as global metabolite profiling, is used to identify metabolic pathways that can be linked to biological mechanisms or clinical outcomes. Targeted metabolomics focuses on specific compounds (or pathways) and is usually more quantitative than untargeted metabolomics.
The FHMS metabolomics facility contains 2 liquid chromatography mass spectrometers (LC-MS) and one gas chromatography MS (GC-MS).
We routinely use targeted LC-MS metabolomics to investigate 24 h rhythms, circadian and sleep/wake processing in a range of species, including humans. Our targeted method (AbsoluteIDQ® p180 Kit, Biocrates) measures amino acids, biogenic amines, acylcarnitines, glycerophospholipids and sphingolipids.
Enquiries
Please contact Dr Dovile Lingaityte regarding analyses (d.lingaityte@surrey.ac.uk).
Metabolomics papers
In recent years we have chosen to focus on LC/MS metabolomics in health and disease in both human and animal studies.
People
Academic lead

Professor Debra Skene
Professor of Neuroendocrinology; Section Lead Chronobiology
Support staff

Dr Dovile Lingaityte
Senior Research Technician (LC-MS), Chronobiology